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IntraLase™ FS Laser

IntraLase™ FS Laser

The Technology Behind LASIK Success

How does AMO's IntraLase™ FS Technology contribute to LASIK success? By delivering biomechanical superiority, excellent visual acuity, and unmatched safety. This innovative technology is also well suited for creating uniquely shaped corneal incisions for corneal transplant surgery.

Increasingly, successful LASIK procedures have one thing in common — they use AMO's IntraLase™ FS Laser System. IntraLase™ FS Technology clearly delivers clinical advantages to enhance your practice.

• Our 4th-generation laser is designed as a primary laser for LASIK procedures and advanced corneal surgery procedures
• 60 kHz performance delivers microkeratome speed and laser precision
• Better biomechanical stability vs. a microkeratome (1)
• Lower induced high-order aberrations vs. a microkeratome (2)
• Better refractive outcomes vs. a microkeratome (2)

*Through three months postoperative

1. Alió JL, Ortiz D, Piñero D. Flap biomechanics with femtosecond and mechanical microkeratomes. Data presented at: European Society of Cataract and Refractive Surgeons; September 10-14, 2005; Lisbon, Portugal.
2. Durrie DS, Kezirian GM. Femtosecond laser versus mechanical keratome flaps in wavefront-guided in situ keratomileusis: prospective contralateral eye study. J Cataract Refract Surg. 2005;31(1):120-126.

At a nearly unprecedented level, LASIK has become a trusted way for people to improve their functional vision. And judging by the numbers, the IntraLase Method, using AMO's IntraLase™ FS Technology, has become an integral part of today's advanced LASIK procedure. With well over 1 million procedures completed to date, IntraLase™ FS Technology is clearly in the DNA of your successful practice. This seemingly genetic link between IntraLase™ FS Laser System and your LASIK practice exists because:

• Patients want all-laser LASIK, and we're the all-laser pioneers
• Surgeons believe in the safety, effectiveness and profitability profile of the IntraLase™ FS laser
• The future of refractive surgery hinges on the innovative application of scientific breakthroughs, and IntraLase™ FS Technology is at the forefront

Maintaining the integrity of the corneal biomechanics is a critical element in the success of the refractive procedure — and only AMO IntraLase™ FS Laser System delivers unmatched control over flap diameter, depth, centration and morphology, resulting in an unprecedented combination of potential advantages, including:

• Controlled Flap Structure
   • Precisely centered, accurately sized flaps; programmable hinge placement1
   • Flap dimensions designed based on patient factors, such as corneal thickness, steepness, diameter and pupil position
   • Precise control of flap dimensions helps avoid the peripheral lamellar structure, vital to the biomechanical stability of the cornea2

• Uniform Flap Thickness
   • Uniformly thin, planar flaps3
   • Smooth, evenly hydrated, stromal morphology4
   • Reproducible flap thicknesses with profiles that are significantly superior to those achieved by mechanical means (p<0.001)4
   • Maximized residual stromal beds

• Superior Visual Outcomes
   • Rapid visual recovery
       • Day 1: UCVA 20/16 or better in 70% of patients (n=199)5
       • Month 1: Increased contrast sensitivity at all spatial frequencies vs. baseline (n=88)6

   • Better quality of vision
       • Eyes treated with the IntraLase FS Laser System had fewer visual disturbances (haze, glare, sensitivity), less pain, and less dryness than a microkeratome6



1. Data on file, IntraLase Corp.
2. Prof. John Marshall. Sub-Bowman's Keratomileusis vs. PRK. Data presented at: Winter European Society of Cataract and Refractive Surgeons; February 2-4, 2007.
3. Binder PS. Flap dimensions created with the IntraLase FS Laser. J Cataract Refract Surg. 2004;30(1):26-32.
4. Kezirian GM, Stonecipher KG. Comparison of the IntraLase femtosecond laser and mechanical keratomes for laser in situ keratomileusis. J Cataract Refract Surg. 2004;30(4):804-811.
5. Tanzer DJ, Schallhorn S, Brown MC, et al. Comparison of femtosecond vs. mechanical keratome in wavefront-guided LASIK. Data presented at: American Society of Cataract and Refractive Surgery Symposium; April 15-20, 2005; Washington, DC.
6. Durrie D. A randomized, prospective clinical study of LASIK performed with the IntraLase FS laser vs. mechanical microkeratome. Data presented at: American Academy of Ophthalmology; October 23-26, 2004; New Orleans, LA.

In a recent study (Sub-Bowman's Keratomileusis with IntraLase™ FS Laser System vs. PRK), IntraLase treated eyes demonstrated clinically and statistically better visual acuities (uncorrected and best corrected) through one month postop compared to surface treatment.1

• Uncorrected Vision
• Through one week postop, eight times more IntraLase eyes achieved 20/20 or better uncorrected vision compared to PRK eyes1
• Superiority continued at one month, where 45% more IntraLase eyes achieved 20/20 or better uncorrected vision compared to PRK eyes1
• Best Corrected Vision
• Clinically and statistically significant improvement through one month with LASIK with the IntraLase Method over PRK when comparing baseline BCVA and postop BCVA1
• At one month, more than twice as many IntraLase eyes showed BCVA gain compared to PRK eyes1

1. Data on file, IntraLase Corp.

By replacing the blade commonly used for corneal flap creation with a femtosecond laser, AMO® has made LASIK eye surgery safer than ever before. The IntraLase™ FS Laser System delivers micron-level accuracy 100% greater1,2 than a microkeratome for more accurate and consistent flap thickness — which is critical for a successful LASIK outcome.

Retrospective analysis comparing LASIK results with IntraLase™ FS Technology versus the two leading microkeratomes demonstrated that IntraLase™ FS Laser System performed better in three areas important to LASIK results and safety: flap thickness, induced astigmatism, and cell injury.3 There are fewer flap-related complications with the IntraLase Method:*4

• Minimal risk of sight-threatening events (free caps, globe penetration, buttonhole flaps, decentered flaps, and/or incomplete cuts)
• No risk of corneal abrasion
• Reduced risk of dry eye

*Only the IntraLase™ FS Laser System can be used to perform the IntraLase Method.

1. Wang M. Femtosecond technology: Is now the time to buy? Refractive Eyecare for Ophthalmologists. May 2003;5:7.
2. Talamo JH. Optimizing flap outcomes with the IntraLase™ FS laser. Ophthalmol Management. May 2004.
3. Kezirian GM, Stonecipher KG. Comparison of the IntraLase™ femtosecond laser and mechanical keratomes for laser in situ keratomileusis. J Cataract Refract Surg. 2004;30(4):804-811.
4. Will B, Kurtz RM. IntraLase™ is best. In: Probst LE, ed. LASIK: Advances, Controversies, and Custom. Thorofare, NJ: SLACK; 2004:397-402.

IntraLase™ enabled keratoplasty gives surgeons the ability to precisely create uniquely shaped corneal incisions — opening a new era in corneal transplantation and delivering the potential for faster healing and improved visual recovery. Leading corneal surgeons have demonstrated that this technology advancement enables:

• Surgeons to create straight, angled and arcuate incisions within the cornea
        • Multiplanar custom incisions with hermetic sealing properties that require less suture tension
        • Less suture tension can result in less astigmatism1
• Multiplanar custom incisions provide larger wound surface area for stronger healing
• Laser resectioning that produces more rapid healing1
• Earlier suture removal and rapid visual rehabilitation1

1. Steinert RF. Femtosecond laser corneal surgery. Data presented at: American Academy of Ophthalmology, November 11-13, 2006; Las Vegas, NV.
2. Photos and personal communication, Francis W Price, Jr, MD.